TBX5

Across TCGA pan-cancer cohorts, TBX5 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TBX5 data layer compared with 6 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TBX5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TBX5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

SKCM, BLCA, and ACC are the cancer types where TBX5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.731	0.537	<.001	76	view →
BLCA	OS	Tertile	All	0.550	0.719	.001	61	view →
ACC	OS	Quartile	All	0.281	0.756	.001	48	view →
KIRC	DFS	Tertile	IV	0.347	0.625	.001	41	view →
LUSC	DFS	Median	II,III,IV	0.495	0.691	.002	36	view →
LUAD	OS	Quartile	II,III,IV	0.656	0.289	<.001	34	view →
COAD	OS	Median	All	0.709	0.864	.001	31	view →
UCEC	DFS	Quartile	All	0.533	0.680	<.001	30	view →
LIHC	OS	Tertile	All	0.421	0.607	.001	29	view →
READ	OS	Quartile	III,IV	0.633	0.942	.014	14	view →
THYM	DFS	Quartile	All	0.786	0.958	.004	12	view →
HNSC	DFS	Quartile	IV	0.468	0.321	.026	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TBX5–SKCM (DFS)

Open the SKCM breakdown →