TBX5

Across TCGA pan-cancer cohorts, TBX5 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of TBX5’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TBX5 RNA is repressed in tumor relative to normal tissue. In most cancer types TBX5 is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and COAD are the cancer types where TBX5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBX5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.365	<.001	9	view →
LUAD	Female	III,IV	−1.643	<.001	9	view →
COAD	All	II,III,IV	+0.241	.002	9	view →
LUSC	Female	All	−2.007	<.001	8	view →
THCA	All	II,III,IV	−0.534	<.001	7	view →
HNSC	All	All	+0.256	.007	4	view →
BRCA	All	All	−0.224	.021	4	view →
KIRC	All	All	+0.233	.020	3	view →
PRAD	All	All	−0.894	<.001	2	view →
UCEC	All	II,III,IV	−0.050	.043	2	view →
READ	Male	All	+0.026	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

TBX5–BLCA

Open the BLCA breakdown →