TBX5

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TBX5 protein abundance is significantly associated with the RNA expression of many other genes, with 4,714 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TBX5-associated genes across cancer lineages are CDKN3, SLC8A3, and SUV39H1. Each is linked with TBX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX5-to-partner and partner-to-TBX5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TBX5 versus CDKN3 in LUAD, with a Pearson correlation of -0.39.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX5→partner) and Y-score (partner→TBX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADCDKN3 →-0.895-0.518.007.00132
LUADSLC8A3 →+0.483+0.629<.001<.00132
LSCCSUV39H1 →-0.638-0.552<.001<.00132
LUADRGCC →+0.845+0.520<.001<.00132
LUADWFDC1 →+0.886+0.573.001.00132
LUADFOXF1 →+0.660+0.586<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 4,714 associations by consensus.

TBX5 vs CDKN3 — LUAD

Per-sample scatter of TBX5 vs CDKN3 in LUAD (Pearson r = -0.39).

Explore this scatter interactively →

Exploration