TBX5

Across TCGA patient cohorts, TBX5 mutation is significantly associated with the total protein of many other genes, with 74 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX5-associated genes across cancer lineages are FoxM1, c-Kit, and 4E-BP1. Each is linked with TBX5 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBX5-to-partner and partner-to-TBX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TBX5-low versus TBX5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX5→partner) and Y-score (partner→TBX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	FoxM1 →	+0.304	+3.331	.023	.005	3	4
UCEC	c-Kit →	-0.144	-1.241	.035	.015	3	4
UCEC	4E-BP1 →	+0.295	+3.906	<.001	<.001	3	3
UCEC	C-Raf →	+0.185	+2.070	<.001	.001	3	3
UCEC	PCNA →	+0.204	+1.637	.001	.001	3	3
UCEC	PRAS40_pT246 →	+0.172	+1.807	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

FoxM1 by TBX5 expression — LUSC

Explore this box plot interactively →