TBX5

Across TCGA cell cohorts, TBX5 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,159 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TBX5-associated GO terms across cancer lineages are COPII vesicle coating, Cardiac septum cell differentiation, and Cell migration involved in vasculogenesis. Each is linked with TBX5 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBX5-to-partner and partner-to-TBX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPII vesicle coating grouped by TBX5-low versus TBX5-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX5→partner) and Y-score (partner→TBX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	COPII vesicle coating →	+0.073	+2.056	.002	.002	3	4
STOMACH	Cardiac septum cell differentiation →	-0.326	-1.013	.003	.001	3	3
LUNG_SCLC	Cell migration involved in vasculogenesis →	-0.228	-1.223	<.001	<.001	3	3
STOMACH	Atrioventricular node cell differentiation →	-0.326	-1.013	.003	.001	3	3
STOMACH	Atrioventricular node cell development →	-0.326	-1.013	.003	.001	3	3
LUNG_SCLC	Negative regulation of double-strand break repair via homologous recombination →	+0.064	+0.847	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,159 associations by consensus.

COPII vesicle coating by TBX5 expression — BONE

Explore this box plot interactively →