TBX5

Across TCGA cell cohorts, TBX5 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TBX5-associated genes across cancer lineages are SGCZ, PRAMEF27, and CEACAM4. Each is linked with TBX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX5-to-partner and partner-to-TBX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SGCZ grouped by TBX5-low versus TBX5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX5→partner) and Y-score (partner→TBX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SGCZ →	+0.023	+2.882	<.001	.005	3	2
LUNG_SCLC	PRAMEF27 →	+0.015	+4.643	<.001	.004	3	1
CNS	CEACAM4 →	+0.030	+5.321	.004	.005	3	1
LUNG_NSCLC_LUAD	GABRA6 →	+0.066	+4.189	<.001	.002	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.013	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	CCDC105 →	+0.003	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

SGCZ by TBX5 expression — LARGE_INTESTINE

Explore this box plot interactively →