TBX21

Across TCGA cell cohorts, TBX21 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TBX21-associated genes across cancer lineages are REG1B, ZCCHC2, and SKA1. Each is linked with TBX21 in more than 1 cancer types. Because this analysis shows association rather than direction, both TBX21-to-partner and partner-to-TBX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG1B grouped by TBX21-low versus TBX21-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX21→partner) and Y-score (partner→TBX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	REG1B →	+0.052	+3.678	<.001	.001	3	2
LARGE_INTESTINE	ZCCHC2 →	+0.911	+3.067	.002	.009	3	1
LARGE_INTESTINE	SKA1 →	+0.875	+3.067	.004	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.017	+3.000	.001	.005	3	1
LARGE_INTESTINE	MAK16 →	+0.899	+3.067	.001	.009	3	1
LARGE_INTESTINE	TBC1D3 →	+0.042	+3.009	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

REG1B by TBX21 expression — SKIN

Explore this box plot interactively →