TBX21

Across TCGA pan-cancer cohorts, TBX21 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TBX21 data layer compared with 4 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TBX21 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TBX21 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and LIHC are the cancer types where TBX21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.415	0.268	<.001	147	view →
HNSC	DFS	Tertile	All	0.683	0.515	<.001	96	view →
LIHC	DFS	Median	All	0.624	0.459	<.001	75	view →
CESC	DFS	Tertile	II,III,IV	0.700	0.375	.003	62	view →
UCEC	OS	Quartile	All	0.785	0.554	.005	58	view →
BLCA	OS	Median	All	0.532	0.229	.003	52	view →
UVM	OS	Quartile	All	0.371	0.773	.001	51	view →
LGG	OS	Median	All	0.736	0.874	<.001	47	view →
BRCA	OS	Median	II,III,IV	0.623	0.512	.001	38	view →
OV	OS	Median	II,III,IV	0.732	0.652	.002	30	view →
SARC	OS	Median	All	0.829	0.661	<.001	22	view →
ESCA	DFS	Tertile	III,IV	0.471	0.206	.011	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TBX21–SKCM (OS)

Open the SKCM breakdown →