TBX15

Across TCGA patient cohorts, TBX15 mutation is significantly associated with the RNA expression of many other genes, with 4,362 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBX15-associated genes across cancer lineages are BUB3, TYMSOS, and RIOK1. Each is linked with TBX15 in more than 3 cancer types. Because this analysis shows association rather than direction, both TBX15-to-partner and partner-to-TBX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB3 grouped by TBX15-low versus TBX15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBX15→partner) and Y-score (partner→TBX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB3 →	+0.488	+2.981	<.001	<.001	3	4
UCEC	TYMSOS →	+0.909	+2.676	<.001	<.001	3	4
LUSC	RIOK1 →	+0.589	+3.333	.001	.005	3	3
LUAD	CCSAP →	+0.432	+3.330	.007	.005	3	3
UCEC	EXOSC3 →	+0.369	+3.016	.005	<.001	3	3
UCEC	MLEC →	+0.347	+1.662	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,362 associations by consensus.

BUB3 by TBX15 expression — UCEC

Explore this box plot interactively →