TBX15

Across TCGA pan-cancer cohorts, TBX15 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TBX15’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TBX15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBX15 is over-expressed in tumor, although a few such as BRCA and CHOL show the opposite, repressed pattern.

KIRC, COAD, and LUAD are the cancer types where TBX15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBX15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.603	<.001	12	view →
COAD	Male	II,III,IV	+0.612	<.001	12	view →
LUAD	Male	II,III,IV	+2.119	<.001	9	view →
KIRP	All	II,III,IV	+2.103	<.001	9	view →
KICH	Male	All	+3.394	<.001	8	view →
STAD	Male	All	+0.454	<.001	7	view →
BRCA	All	III,IV	−1.584	<.001	6	view →
UCEC	All	All	+1.083	<.001	6	view →
CHOL	All	All	−3.581	<.001	5	view →
LIHC	Male	II,III,IV	−2.354	<.001	4	view →
PAAD	All	All	+1.542	.024	4	view →
LUSC	Male	All	+0.834	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TBX15–KIRC

Open the KIRC breakdown →