TBP

Across TCGA patient cohorts, TBP mutation is significantly associated with the RNA expression of many other genes, with 1,164 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBP-associated genes across cancer lineages are RN7SL248P, MIR3118-3, and YTHDF3-AS1. Each is linked with TBP in more than 2 cancer types. Because this analysis shows association rather than direction, both TBP-to-partner and partner-to-TBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by TBP-low versus TBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBP→partner) and Y-score (partner→TBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.059	+3.137	<.001	.005	3	3
BRCA	MIR3118-3 →	+0.371	+7.471	<.001	.008	3	1
UCEC	YTHDF3-AS1 →	+0.669	+2.617	<.001	.005	3	1
UCEC	LINC01050 →	+0.166	+1.895	.002	.003	3	1
UCEC	MAP3K4-AS1 →	+0.799	+3.008	<.001	<.001	3	1
UCEC	ZNHIT3 →	+0.473	+2.930	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,164 associations by consensus.

RN7SL248P by TBP expression — UCEC

Explore this box plot interactively →