TBP

Across TCGA pan-cancer cohorts, TBP RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TBP data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher TBP RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TBP expression acts as an unfavorable survival marker, although some lineages such as READ and SKCM show a favorable association.

OV, LIHC, and MESO are the cancer types where TBP RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	III,IV	0.782	0.885	.002	88	view →
LIHC	OS	Median	All	0.706	0.845	<.001	86	view →
MESO	DFS	Median	II,III,IV	0.290	0.611	.006	55	view →
READ	OS	Median	All	0.967	0.316	.001	41	view →
KIRC	DFS	Median	IV	0.498	0.745	.010	33	view →
BRCA	OS	Quartile	All	0.434	0.706	<.001	29	view →
SKCM	OS	Median	III,IV	0.867	0.754	.003	27	view →
ESCA	OS	Quartile	II,III,IV	0.541	0.850	.001	27	view →
KIRP	DFS	Quartile	III,IV	0.167	0.720	.005	25	view →
CESC	DFS	Tertile	All	0.667	0.817	.007	24	view →
ACC	DFS	Quartile	All	0.387	0.842	.001	24	view →
STAD	DFS	Median	IV	0.186	0.580	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TBP–OV (OS)

Open the OV breakdown →