TBCB

Across TCGA patient cohorts, TBCB mutation is significantly associated with the RNA expression of many other genes, with 850 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBCB-associated genes across cancer lineages are RNA5SP198, RNA5SP205, and MTND4LP21. Each is linked with TBCB in more than 2 cancer types. Because this analysis shows association rather than direction, both TBCB-to-partner and partner-to-TBCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by TBCB-low versus TBCB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBCB→partner) and Y-score (partner→TBCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP198 →	+0.526	+3.036	<.001	.009	3	3
UCEC	RNA5SP205 →	+0.462	+3.267	<.001	.005	3	2
SKCM	MTND4LP21 →	+0.083	+4.385	<.001	.008	3	2
SKCM	LINC00604 →	+0.121	+4.351	.001	.002	3	1
SKCM	PDCD5P2 →	+0.159	+4.156	.007	.004	3	1
SKCM	KRT18P6 →	+0.112	+4.287	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 850 associations by consensus.

RNA5SP198 by TBCB expression — UCEC

Explore this box plot interactively →