TBCB

Across TCGA pan-cancer cohorts, TBCB RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TBCB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TBCB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBCB is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where TBCB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBCB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+1.152	<.001	12	view →
HNSC	Male	III,IV	+0.904	<.001	12	view →
LIHC	Male	II,III,IV	+1.297	<.001	9	view →
KICH	Female	II,III,IV	−1.247	<.001	8	view →
KIRC	All	All	+0.280	<.001	7	view →
BRCA	All	III,IV	+0.818	<.001	6	view →
KIRP	All	II,III,IV	+0.521	.002	6	view →
THCA	All	II,III,IV	+0.397	<.001	6	view →
LUSC	All	All	+0.559	<.001	5	view →
BLCA	All	All	+0.515	.019	4	view →
STAD	All	II,III,IV	+0.492	.003	4	view →
CHOL	All	All	+2.334	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TBCB–COAD

Open the COAD breakdown →