TBCB

Across TCGA pan-cancer cohorts, TBCB RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TBCB data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TBCB RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBCB expression acts as an unfavorable survival marker, although some lineages such as SCLC and BRCA show a favorable association.

ACC, UVM, and KIRC are the cancer types where TBCB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.210	0.686	<.001	119	view →
UVM	OS	Quartile	All	0.507	0.847	.001	88	view →
KIRC	DFS	Tertile	All	0.810	0.948	.001	70	view →
LIHC	OS	Tertile	All	0.586	0.760	<.001	54	view →
LGG	DFS	Median	All	0.660	0.812	<.001	39	view →
SCLC	DFS	Quartile	II,III,IV	0.827	0.396	.010	29	view →
LAML	DFS	Median	All	0.416	0.717	.002	28	view →
PRAD	DFS	Tertile	All	0.700	0.893	<.001	18	view →
MESO	OS	Quartile	All	0.389	0.680	.004	16	view →
READ	OS	Median	II,III,IV	0.336	0.839	.018	14	view →
BRCA	OS	Median	All	0.644	0.455	.005	13	view →
CHOL	OS	Quartile	II,III,IV	0.961	0.170	.004	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TBCB–ACC (DFS)

Open the ACC breakdown →