TBCB

Across TCGA patient cohorts, TBCB mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBCB-associated genes across cancer lineages are FoxM1, p27_pT198, and Rab11. Each is linked with TBCB in more than 1 cancer types. Because this analysis shows association rather than direction, both TBCB-to-partner and partner-to-TBCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by TBCB-low versus TBCB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBCB→partner) and Y-score (partner→TBCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.270	+3.321	.047	.010	3	1
UCEC	p27_pT198 →	+0.145	+3.321	.009	.010	3	1
UCEC	Rab11 →	-0.150	-3.321	.048	.010	3	1
UCEC	eIF4E →	+0.242	+3.321	.028	.010	1	1
UCEC	Rad50 →	-0.330	-3.321	.009	.010	1	1
UCEC	TAZ →	-0.183	-3.321	.013	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

FoxM1 by TBCB expression — UCEC

Explore this box plot interactively →