TBCB

Across TCGA cell cohorts, TBCB mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBCB-associated genes across cancer lineages are HOXD1, OR11H1, and OR4K2. Each is linked with TBCB in more than 1 cancer types. Because this analysis shows association rather than direction, both TBCB-to-partner and partner-to-TBCB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HOXD1 grouped by TBCB-low versus TBCB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBCB→partner) and Y-score (partner→TBCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HOXD1 →	+0.187	+4.222	<.001	.003	3	1
BLOOD_Leukemia	OR11H1 →	+0.082	+4.786	<.001	<.001	3	1
BLOOD_Leukemia	OR4K2 →	+0.025	+4.384	<.001	.006	3	1
BLOOD_Leukemia	RXFP3 →	+0.008	+3.874	.005	.005	3	1
BLOOD_Leukemia	OR11G2 →	+0.237	+4.507	<.001	.001	3	1
BLOOD_Leukemia	PRR23A →	+0.060	+4.269	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

HOXD1 by TBCB expression — BLOOD_Leukemia

Explore this box plot interactively →