TBC1D3D

Across TCGA cell cohorts, TBC1D3D RNA expression is significantly associated with the go_rna of many other GO terms, with 1,521 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TBC1D3D-associated GO terms across cancer lineages are Target-directed miRNA degradation, Negative regulation of cytoplasmic pattern recognition receptor signaling pathway, and mRNA 5'-splice site recognition. Each is linked with TBC1D3D in more than 7 cancer types. Because this analysis shows association rather than direction, both TBC1D3D-to-partner and partner-to-TBC1D3D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Target-directed miRNA degradation grouped by TBC1D3D-low versus TBC1D3D-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D3D→partner) and Y-score (partner→TBC1D3D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Target-directed miRNA degradation →	+0.081	+1.285	.004	.002	3	8
PANCREAS	Negative regulation of cytoplasmic pattern recognition receptor signaling pathway →	+0.050	+1.154	<.001	<.001	3	7
LARGE_INTESTINE	mRNA 5'-splice site recognition →	+0.111	+0.576	.002	.003	3	6
BLOOD_Leukemia	Positive regulation of ruffle assembly →	+0.054	+0.465	.002	.001	3	6
STOMACH	tRNA 5'-end processing →	-0.105	-0.504	<.001	.004	3	6
LARGE_INTESTINE	Regulation of cytoplasmic mRNA processing body assembly →	+0.084	+0.510	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,521 associations by consensus.

Target-directed miRNA degradation by TBC1D3D expression — PANCREAS

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