TBC1D2B

Across TCGA patient cohorts, TBC1D2B mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D2B-associated genes across cancer lineages are ATM, PDCD4, and Annexin-1. Each is linked with TBC1D2B in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D2B-to-partner and partner-to-TBC1D2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TBC1D2B-low versus TBC1D2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D2B→partner) and Y-score (partner→TBC1D2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.461	-3.156	.001	<.001	3	3
UCEC	PDCD4 →	-0.427	-2.222	.003	.009	3	2
UCEC	Annexin-1 →	+0.712	+2.267	<.001	<.001	3	2
UCEC	TFRC →	+0.452	+1.353	.006	.015	3	2
UCEC	Caspase-7-cleavedD198 →	+0.561	+1.697	.002	.012	3	2
UCEC	c-Kit →	-0.180	-1.584	.014	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ATM by TBC1D2B expression — UCEC

Explore this box plot interactively →