TBC1D2B

Across TCGA pan-cancer cohorts, TBC1D2B RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of TBC1D2B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TBC1D2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TBC1D2B is over-expressed in tumor, although a few such as UCEC and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and UCEC are the cancer types where TBC1D2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TBC1D2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.359	<.001	11	view →
KIRC	Male	All	+1.011	<.001	11	view →
UCEC	All	All	−1.859	<.001	6	view →
LUSC	All	II,III,IV	−0.631	<.001	6	view →
BRCA	All	All	−0.586	<.001	6	view →
LUAD	Female	All	−0.580	<.001	6	view →
STAD	Male	II,III,IV	+1.021	.002	5	view →
THCA	All	All	−0.407	<.001	4	view →
CHOL	All	All	+1.241	.003	2	view →
PRAD	All	All	−0.243	.047	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

TBC1D2B–HNSC

Open the HNSC breakdown →