TBC1D2B

Across TCGA pan-cancer cohorts, TBC1D2B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TBC1D2B data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TBC1D2B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TBC1D2B expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

LUSC, LGG, and KIRP are the cancer types where TBC1D2B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Tertile	III,IV	0.252	0.935	.002	46	view →
LGG	DFS	Median	All	0.658	0.818	<.001	45	view →
KIRP	DFS	Median	III,IV	0.439	0.751	.011	35	view →
KIRC	DFS	Median	All	0.867	0.723	.001	31	view →
BRCA	OS	Tertile	III,IV	0.905	0.742	.001	27	view →
SKCM	DFS	Median	II,III,IV	0.739	0.636	.006	24	view →
LAML	DFS	Tertile	All	0.675	0.489	.032	20	view →
HNSC	DFS	Median	All	0.413	0.290	.004	14	view →
MESO	OS	Quartile	All	0.683	0.411	.007	14	view →
ESCA	DFS	Quartile	III,IV	0.659	0.359	.011	9	view →
LUAD	OS	Tertile	III,IV	0.574	0.246	.018	9	view →
OV	OS	Quartile	III,IV	0.251	0.378	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TBC1D2B–LUSC (DFS)

Open the LUSC breakdown →