TBC1D2B

Across TCGA cell cohorts, TBC1D2B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,397 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TBC1D2B-associated GO terms across cancer lineages are Negative regulation of transcription initiation by RNA polymerase II, Negative regulation of DNA-templated transcription initiation, and Cell division. Each is linked with TBC1D2B in more than 14 cancer types. Because this analysis shows association rather than direction, both TBC1D2B-to-partner and partner-to-TBC1D2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of transcription initiation by RNA polymerase II grouped by TBC1D2B-low versus TBC1D2B-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D2B→partner) and Y-score (partner→TBC1D2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of transcription initiation by RNA polymerase II →	+0.118	+0.731	<.001	<.001	3	15
STOMACH	Negative regulation of DNA-templated transcription initiation →	+0.118	+0.731	<.001	<.001	3	15
OESOPHAGUS	Cell division →	+0.078	+0.831	.001	.003	3	14
CNS	Endocytic recycling →	+0.056	+0.696	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.075	+1.239	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Cytosolic transport →	+0.090	+1.127	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,397 associations by consensus.

Negative regulation of transcription initiation by RNA polymerase II by TBC1D2B expression — STOMACH

Explore this box plot interactively →