TBC1D2B

Across TCGA cell cohorts, TBC1D2B mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TBC1D2B-associated genes across cancer lineages are GOLGA6C, TMEM95, and USP17L4. Each is linked with TBC1D2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D2B-to-partner and partner-to-TBC1D2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GOLGA6C grouped by TBC1D2B-low versus TBC1D2B-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D2B→partner) and Y-score (partner→TBC1D2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GOLGA6C →	+0.069	+3.791	.004	.007	3	2
LUNG_NSCLC_LUAD	TMEM95 →	+0.017	+3.544	.001	.009	3	1
LUNG_NSCLC_LUAD	USP17L4 →	+0.037	+3.760	<.001	.008	3	1
SKIN	OR11G2 →	+0.010	+3.930	<.001	.003	3	1
SKIN	GUCA2A →	+0.050	+4.688	.005	<.001	3	1
BLOOD_Leukemia	CCDC158 →	+0.035	+3.734	.006	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GOLGA6C by TBC1D2B expression — SKIN

Explore this box plot interactively →