TBC1D24

Across TCGA patient cohorts, TBC1D24 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D24-associated genes across cancer lineages are Rictor_pT1135, eEF2, and eIF4E. Each is linked with TBC1D24 in more than 2 cancer types. Because this analysis shows association rather than direction, both TBC1D24-to-partner and partner-to-TBC1D24 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by TBC1D24-low versus TBC1D24-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D24→partner) and Y-score (partner→TBC1D24) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Rictor_pT1135 →	-0.175	-2.974	.037	.035	3	3
UCEC	eEF2 →	+0.269	+2.321	.041	.033	3	2
UCEC	eIF4E →	+0.169	+1.502	.029	.030	3	2
COAD	INPP4B →	-0.464	-2.991	.016	.036	3	2
UCEC	mTOR_pS2448 →	-0.142	-2.095	.009	.017	3	2
COAD	Rad50 →	-0.368	-2.991	.003	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Rictor_pT1135 by TBC1D24 expression — SKCM

Explore this box plot interactively →