TBC1D24

Across TCGA pan-cancer cohorts, TBC1D24 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TBC1D24 data layer compared with 7 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher TBC1D24 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TBC1D24 expression acts as an unfavorable survival marker, although some lineages such as READ and LUAD show a favorable association.

BRCA, READ, and MESO are the cancer types where TBC1D24 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	III,IV	0.361	0.696	<.001	72	view →
READ	OS	Median	All	0.965	0.320	.002	53	view →
MESO	OS	Quartile	All	0.213	0.436	.011	45	view →
LUAD	OS	Tertile	All	0.892	0.730	.002	29	view →
KIRP	DFS	Quartile	All	0.743	0.920	.010	28	view →
CESC	DFS	Median	All	0.767	0.871	.008	24	view →
KIRC	DFS	Median	II,III,IV	0.439	0.627	.007	20	view →
STAD	DFS	Quartile	All	0.757	0.544	.005	20	view →
HNSC	OS	Tertile	All	0.576	0.818	.004	16	view →
PCPG	DFS	Tertile	All	0.960	0.731	.009	14	view →
THCA	OS	Tertile	II,III,IV	0.923	1.000	.016	13	view →
LUSC	DFS	Tertile	III,IV	0.608	1.000	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TBC1D24–BRCA (OS)

Open the BRCA breakdown →