TBC1D22B

Across TCGA patient cohorts, TBC1D22B mutation is significantly associated with the RNA expression of many other genes, with 2,193 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TBC1D22B-associated genes across cancer lineages are MIR941-5, MIR4418, and LINC02707. Each is linked with TBC1D22B in more than 1 cancer types. Because this analysis shows association rather than direction, both TBC1D22B-to-partner and partner-to-TBC1D22B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR941-5 grouped by TBC1D22B-low versus TBC1D22B-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TBC1D22B→partner) and Y-score (partner→TBC1D22B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR941-5 →	+0.299	+5.038	<.001	.003	3	2
BRCA	MIR4418 →	+0.344	+4.866	<.001	.003	3	2
SKCM	LINC02707 →	+0.184	+3.300	<.001	.007	3	2
UCEC	FRG1HP →	+0.540	+3.721	<.001	<.001	3	2
UCEC	MRPL45 →	+0.560	+2.747	.002	<.001	3	2
BRCA	SNORD38A →	+0.590	+3.788	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,193 associations by consensus.

MIR941-5 by TBC1D22B expression — BRCA

Explore this box plot interactively →