Across TCGA cell cohorts, TAT mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TAT-associated genes across cancer lineages are C4orf50, TRIM77, and GPR101. Each is linked with TAT in more than 1 cancer types. Because this analysis shows association rather than direction, both TAT-to-partner and partner-to-TAT results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAT→partner) and Y-score (partner→TAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C4orf50 →	+0.013	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	TRIM77 →	+0.030	+5.357	<.001	.003	3	1
BLOOD_Leukemia	GPR101 →	+0.128	+4.551	<.001	.004	3	1
BLOOD_Leukemia	OR10T2 →	+0.584	+4.276	.005	.007	3	1
BLOOD_Leukemia	USP17L20 →	+0.004	+4.539	<.001	.007	3	1
BLOOD_Leukemia	USP17L18 →	+0.004	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

TAT survival (RNA) · tumor vs normal (RNA) · all TAT data types