Across TCGA pan-cancer cohorts, TAT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TAT’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where TAT RNA is repressed in tumor relative to normal tissue. In most cancer types TAT is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.
COAD, KICH, and LIHC are the cancer types where TAT tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAT RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.