TAS2R9

Across TCGA patient cohorts, TAS2R9 mutation is significantly associated with the RNA expression of many other genes, with 2,432 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R9-associated genes across cancer lineages are IGHVII-1-1, RFC4, and DACT2. Each is linked with TAS2R9 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAS2R9-to-partner and partner-to-TAS2R9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHVII-1-1 grouped by TAS2R9-low versus TAS2R9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R9→partner) and Y-score (partner→TAS2R9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IGHVII-1-1 →	+0.197	+7.741	<.001	.009	3	3
UCEC	RFC4 →	+0.626	+3.000	.006	.001	3	2
UCEC	DACT2 →	-1.663	-3.799	<.001	<.001	3	2
UCEC	NDUFB6 →	+0.599	+3.700	<.001	.001	3	2
UCEC	EIF2B3 →	+0.373	+2.321	.008	.006	3	2
UCEC	ARVCF →	+0.700	+3.616	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,432 associations by consensus.

IGHVII-1-1 by TAS2R9 expression — COAD

Explore this box plot interactively →