Across TCGA patient cohorts, TAS2R40 mutation is significantly associated with the RNA expression of many other genes, with 887 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R40-associated genes across cancer lineages are TRAJ26, TRDD1, and GPATCH11. Each is linked with TAS2R40 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R40-to-partner and partner-to-TAS2R40 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R40→partner) and Y-score (partner→TAS2R40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TRAJ26 →	+0.667	+4.480	<.001	.005	3	2
BRCA	TRDD1 →	+1.367	+9.057	<.001	.003	3	2
UCEC	GPATCH11 →	+0.514	+3.365	.003	.004	3	2
BLCA	OR6C68 →	+0.068	+6.814	<.001	<.001	3	2
UCEC	HYKK →	+0.478	+3.711	<.001	<.001	3	2
UCEC	C1orf174 →	+0.461	+2.595	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 887 associations by consensus.

Exploration

TAS2R40 survival (RNA) · tumor vs normal (RNA) · all TAS2R40 data types