Across TCGA pan-cancer cohorts, TAS2R40 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of TAS2R40’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where TAS2R40 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TAS2R40 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

BRCA and THCA are the cancer types where TAS2R40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAS2R40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	+0.051	.004	4	view →
THCA	Female	All	−0.011	.041	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TAS2R40 RNA expression & survival · all TAS2R40 data types