Across TCGA pan-cancer cohorts, TAS2R40 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated TAS2R40 data layer compared with 7 for mutation status.
The strongest signal is observed in mesothelioma (MESO), where higher TAS2R40 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TAS2R40 expression acts as an unfavorable survival marker, although some lineages such as LUAD and ESCA show a favorable association.
MESO, UCEC, and READ are the cancer types where TAS2R40 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.