Across TCGA patient cohorts, TAS2R40 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAS2R40-associated genes across cancer lineages are Notch1, PCNA, and PDCD4. Each is linked with TAS2R40 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS2R40-to-partner and partner-to-TAS2R40 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS2R40→partner) and Y-score (partner→TAS2R40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.178	+2.817	.021	.036	3	1
UCEC	PCNA →	+0.267	+3.169	.024	.020	3	1
UCEC	PDCD4 →	-0.574	-2.990	.026	.036	3	1
UCEC	VHL →	-0.917	-3.169	.013	.020	3	1
UCEC	CDK1 →	+0.167	+3.169	.044	.020	3	1
UCEC	INPP4B →	-0.412	-3.169	.020	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

TAS2R40 survival (RNA) · tumor vs normal (RNA) · all TAS2R40 data types