TAS1R3

Across TCGA patient cohorts, TAS1R3 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TAS1R3-associated genes across cancer lineages are CD8+ naive T-cells, Adipocytes, and Pericytes. Each is linked with TAS1R3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TAS1R3-to-partner and partner-to-TAS1R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ naive T-cells grouped by TAS1R3-low versus TAS1R3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS1R3→partner) and Y-score (partner→TAS1R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CD8+ naive T-cells →	+0.029	+3.357	.030	.005	3	3
SKCM	Adipocytes →	+0.028	+2.915	.028	.011	3	1
SKCM	Pericytes →	+0.071	+2.591	.015	.024	3	1
UCEC	Class-switched memory B-cells →	-0.060	-2.321	.036	.036	1	1
UCEC	Plasma cells →	-0.022	-3.416	.044	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CD8+ naive T-cells by TAS1R3 expression — BLCA

Explore this box plot interactively →