TAS1R3

Across TCGA pan-cancer cohorts, TAS1R3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TAS1R3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TAS1R3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TAS1R3 is over-expressed in tumor, although a few such as HNSC and KIRP show the opposite, repressed pattern.

LUAD, BLCA, and BRCA are the cancer types where TAS1R3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAS1R3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+1.186	<.001	11	view →
BLCA	Male	III,IV	+1.215	<.001	8	view →
BRCA	Female	II,III,IV	+0.619	<.001	6	view →
THCA	All	All	+0.395	.002	5	view →
HNSC	Male	All	−0.469	.020	4	view →
LUSC	All	All	+0.400	.004	2	view →
KIRP	All	All	−0.308	.001	2	view →
PRAD	All	All	−0.147	.007	2	view →
KICH	Female	II,III,IV	+0.394	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

TAS1R3–LUAD

Open the LUAD breakdown →