TAS1R3

Across TCGA pan-cancer cohorts, TAS1R3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TAS1R3 data layer compared with 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TAS1R3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TAS1R3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where TAS1R3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.400	0.187	<.001	128	view →
SKCM	OS	Median	All	0.433	0.266	<.001	112	view →
UVM	DFS	Tertile	All	0.902	0.532	<.001	65	view →
LUAD	OS	Tertile	III,IV	0.649	0.360	.001	47	view →
ACC	OS	Median	IV	0.842	0.244	.001	32	view →
KIRC	DFS	Median	IV	0.378	0.643	.011	32	view →
STAD	DFS	Quartile	II,III,IV	0.423	0.717	.002	30	view →
LGG	DFS	Median	All	0.648	0.826	<.001	25	view →
SCLC	DFS	Tertile	All	0.776	0.451	.003	24	view →
PAAD	DFS	Quartile	All	0.496	0.174	.002	21	view →
BLCA	DFS	Median	IV	0.265	0.627	.003	15	view →
LIHC	OS	Tertile	All	0.465	0.614	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TAS1R3–HNSC (DFS)

Open the HNSC breakdown →