TAS1R3

Across TCGA cell cohorts, TAS1R3 mutation is significantly associated with the RNA expression of many other genes, with 292 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAS1R3-associated genes across cancer lineages are ZIC5, PDXP, and CLEC4C. Each is linked with TAS1R3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAS1R3-to-partner and partner-to-TAS1R3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZIC5 grouped by TAS1R3-low versus TAS1R3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAS1R3→partner) and Y-score (partner→TAS1R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZIC5 →	+1.083	+3.169	.001	.009	3	2
LARGE_INTESTINE	PDXP →	+0.914	+3.364	<.001	.002	3	2
BREAST	CLEC4C →	+0.022	+5.169	<.001	.005	3	2
STOMACH	AGXT2 →	+0.143	+3.830	<.001	.005	3	2
LUNG_NSCLC_LUAD	KRTAP5-11 →	+0.069	+4.887	<.001	.009	3	2
SOFT_TISSUE	AVP →	+0.078	+4.392	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 292 associations by consensus.

ZIC5 by TAS1R3 expression — LARGE_INTESTINE

Explore this box plot interactively →