TAF1A

Across TCGA cell cohorts, TAF1A mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TAF1A-associated genes across cancer lineages are TCP10L2, TTLL8, and LYZL4. Each is linked with TAF1A in more than 1 cancer types. Because this analysis shows association rather than direction, both TAF1A-to-partner and partner-to-TAF1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCP10L2 grouped by TAF1A-low versus TAF1A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAF1A→partner) and Y-score (partner→TAF1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TCP10L2 →	+0.064	+4.887	<.001	.009	3	1
LARGE_INTESTINE	TTLL8 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	LYZL4 →	+0.222	+3.556	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.025	+4.584	<.001	<.001	3	1
LARGE_INTESTINE	AVPR1B →	+0.021	+3.716	.008	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

TCP10L2 by TAF1A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →