TADA3

Across TCGA patient cohorts, TADA3 mutation is significantly associated with the RNA expression of many other genes, with 700 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TADA3-associated genes across cancer lineages are MIR3689B, TRAJ12, and H2AL1RP. Each is linked with TADA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TADA3-to-partner and partner-to-TADA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3689B grouped by TADA3-low versus TADA3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TADA3→partner) and Y-score (partner→TADA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3689B →	+0.228	+5.309	<.001	.003	3	3
COAD	TRAJ12 →	+0.975	+2.403	<.001	.009	3	2
COAD	H2AL1RP →	+0.291	+2.871	.008	.008	3	2
UCEC	MAP2K3 →	+0.461	+3.828	.001	<.001	3	2
UCEC	ITGAE →	+0.524	+2.518	<.001	.001	3	2
UCEC	BLVRB →	+0.594	+2.332	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 700 associations by consensus.

MIR3689B by TADA3 expression — LUSC

Explore this box plot interactively →