TAC3

Across TCGA patient cohorts, TAC3 mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TAC3-associated genes across cancer lineages are RNU6-618P, FDX1P2, and SNRPGP17. Each is linked with TAC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TAC3-to-partner and partner-to-TAC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-618P grouped by TAC3-low versus TAC3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TAC3→partner) and Y-score (partner→TAC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-618P →	+0.483	+3.969	<.001	<.001	3	2
UCEC	FDX1P2 →	+0.147	+3.216	.004	.002	3	2
UCEC	SNRPGP17 →	+0.352	+2.463	.001	.008	3	1
UCEC	MIR6895 →	+1.102	+4.088	<.001	<.001	3	1
UCEC	RNA5SP412 →	+1.030	+2.967	<.001	.002	3	1
UCEC	CICP28 →	+0.022	+2.766	.007	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

RNU6-618P by TAC3 expression — UCEC

Explore this box plot interactively →