TAC3

Across TCGA pan-cancer cohorts, TAC3 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TAC3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where TAC3 RNA is repressed in tumor relative to normal tissue. In most cancer types TAC3 is over-expressed in tumor, although a few such as KICH and STAD show the opposite, repressed pattern.

KICH, STAD, and COAD are the cancer types where TAC3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TAC3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.110	.003	5	view →
STAD	All	All	−1.122	.015	4	view →
COAD	All	All	−0.367	.004	3	view →
LUSC	All	All	+0.338	.017	3	view →
UCEC	All	All	+0.714	.005	2	view →
LIHC	All	All	+0.294	.003	2	view →
BLCA	Female	IV	+6.060	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TAC3–KICH

Open the KICH breakdown →