SYT9

Across TCGA patient cohorts, SYT9 mutation is significantly associated with the RNA expression of many other genes, with 4,335 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT9-associated genes across cancer lineages are CHEK1, TOMM70, and SASS6. Each is linked with SYT9 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYT9-to-partner and partner-to-SYT9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK1 grouped by SYT9-low versus SYT9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT9→partner) and Y-score (partner→SYT9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CHEK1 →	+0.678	+2.343	<.001	<.001	3	3
UCEC	TOMM70 →	+0.406	+1.979	.004	.002	3	3
UCEC	SASS6 →	+0.543	+3.016	.002	<.001	3	3
SKCM	ZNF761 →	+0.482	+1.926	.005	.009	3	3
UCEC	KIF15 →	+0.668	+2.238	.002	.006	3	3
SKCM	GNL3 →	+0.510	+2.738	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,335 associations by consensus.

CHEK1 by SYT9 expression — UCEC

Explore this box plot interactively →