SYT13

Across TCGA patient cohorts, SYT13 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT13-associated genes across cancer lineages are Caspase-7-cleavedD198, p38-MAPK_pT180_Y182, and Tuberin. Each is linked with SYT13 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYT13-to-partner and partner-to-SYT13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SYT13-low versus SYT13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT13→partner) and Y-score (partner→SYT13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.905	+2.584	.001	.011	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.446	-3.169	.033	.019	2	2
SKCM	Tuberin →	+0.341	+3.321	.043	.010	3	1
UCEC	p27_pT198 →	+0.119	+3.000	.016	.036	2	1
UCEC	Caspase-8 →	-0.263	-3.321	.024	.010	2	1
SKCM	HER3 →	+0.427	+2.186	.047	.034	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Caspase-7-cleavedD198 by SYT13 expression — UCEC

Explore this box plot interactively →