SYT13

Across TCGA pan-cancer cohorts, SYT13 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SYT13’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where SYT13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SYT13 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

BRCA, LUAD, and COAD are the cancer types where SYT13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYT13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	III,IV	+2.846	<.001	8	view →
LUAD	Male	II,III,IV	+2.139	<.001	8	view →
COAD	Female	All	−0.999	.005	7	view →
HNSC	Male	All	+0.503	.009	6	view →
KICH	Female	All	+2.595	<.001	5	view →
STAD	Male	All	+2.091	<.001	4	view →
UCEC	All	II,III,IV	+1.410	.022	4	view →
CHOL	Female	All	+5.976	<.001	3	view →
LUSC	All	All	+1.055	<.001	3	view →
THCA	All	All	−0.614	.005	2	view →
READ	All	All	−1.385	.032	1	view →
LIHC	Female	All	+0.975	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SYT13–BRCA

Open the BRCA breakdown →