SYT13

Across TCGA pan-cancer cohorts, SYT13 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SYT13 data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher SYT13 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SYT13 expression acts as an unfavorable survival marker, although some lineages such as LGG and KIRP show a favorable association.

CESC, UCEC, and LUAD are the cancer types where SYT13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	All	0.589	0.812	<.001	44	view →
UCEC	DFS	Tertile	All	0.790	0.900	<.001	44	view →
LUAD	OS	Median	All	0.622	0.744	<.001	40	view →
UVM	DFS	Median	III,IV	0.211	0.884	.002	36	view →
LGG	DFS	Median	All	0.478	0.287	<.001	31	view →
KIRP	DFS	Median	All	0.978	0.796	.008	28	view →
UCS	OS	Median	III,IV	0.565	0.195	.007	24	view →
THCA	DFS	Quartile	II,III,IV	0.886	0.569	.004	23	view →
BLCA	DFS	Quartile	II,III,IV	0.521	0.667	.005	22	view →
LIHC	OS	Tertile	All	0.690	0.861	.003	22	view →
SKCM	DFS	Median	II,III,IV	0.683	0.511	.013	15	view →
READ	OS	Tertile	III,IV	1.000	0.735	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SYT13–CESC (DFS)

Open the CESC breakdown →