SYT12

Across TCGA patient cohorts, SYT12 mutation is significantly associated with the RNA expression of many other genes, with 754 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYT12-associated genes across cancer lineages are RNU6-633P, UHRF1, and RNU6-176P. Each is linked with SYT12 in more than 2 cancer types. Because this analysis shows association rather than direction, both SYT12-to-partner and partner-to-SYT12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-633P grouped by SYT12-low versus SYT12-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYT12→partner) and Y-score (partner→SYT12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-633P →	+0.453	+3.374	<.001	.008	3	3
SKCM	UHRF1 →	+0.801	+2.591	.004	.006	3	2
READ	RNU6-176P →	+0.468	+6.257	<.001	.001	3	2
BLCA	LINC02769 →	+0.781	+5.038	<.001	.009	3	2
READ	MTCO3P39 →	+0.107	+5.039	<.001	.008	3	2
READ	ANKRD20A6P →	+0.261	+5.925	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 754 associations by consensus.

RNU6-633P by SYT12 expression — COAD

Explore this box plot interactively →