SYT12

Across TCGA pan-cancer cohorts, SYT12 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SYT12’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SYT12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SYT12 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

THCA, LUAD, and KIRP are the cancer types where SYT12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYT12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	+5.013	<.001	11	view →
LUAD	All	III,IV	+2.592	<.001	9	view →
KIRP	Male	II,III,IV	+1.608	<.001	9	view →
KICH	All	All	−0.446	<.001	9	view →
KIRC	Male	All	+0.827	<.001	7	view →
LUSC	Male	II,III,IV	+1.290	<.001	6	view →
HNSC	All	All	+0.646	.001	6	view →
COAD	All	IV	+0.154	<.001	6	view →
BLCA	Male	III,IV	+0.484	.005	2	view →
STAD	Female	All	+0.365	.048	2	view →
READ	All	III,IV	+0.095	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SYT12–THCA

Open the THCA breakdown →