SYPL1

Across TCGA patient cohorts, SYPL1 mutation is significantly associated with the RNA expression of many other genes, with 407 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYPL1-associated genes across cancer lineages are ATXN3L, RNU1-14P, and RNU6-78P. Each is linked with SYPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SYPL1-to-partner and partner-to-SYPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATXN3L grouped by SYPL1-low versus SYPL1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYPL1→partner) and Y-score (partner→SYPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	ATXN3L →	+0.017	+5.252	<.001	.002	3	1
CESC	RNU1-14P →	+0.357	+5.124	<.001	<.001	3	1
CESC	RNU6-78P →	+0.379	+5.554	<.001	<.001	3	1
CESC	RNU6-1056P →	+0.351	+4.304	.006	.003	3	1
CESC	AZGP1P2 →	+0.100	+4.196	<.001	.003	3	1
CESC	MIR1302-7 →	+0.353	+5.252	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 407 associations by consensus.

ATXN3L by SYPL1 expression — CESC

Explore this box plot interactively →