SYPL1

Across TCGA pan-cancer cohorts, SYPL1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SYPL1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SYPL1 RNA is repressed in tumor relative to normal tissue. In most cancer types SYPL1 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

THCA, LIHC, and UCEC are the cancer types where SYPL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SYPL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.007	<.001	10	view →
LIHC	Female	All	+1.115	<.001	9	view →
UCEC	All	All	−1.343	<.001	6	view →
HNSC	Female	III,IV	+0.856	.007	6	view →
CHOL	Male	All	+2.008	<.001	5	view →
LUSC	All	All	+0.513	<.001	4	view →
COAD	Male	All	+0.479	<.001	4	view →
PAAD	Male	All	+0.705	.027	2	view →
KICH	All	All	−0.333	.027	2	view →
PRAD	All	All	−0.320	.003	2	view →
ESCA	All	All	+0.740	.029	1	view →
KIRC	All	II,III,IV	−0.248	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SYPL1–THCA

Open the THCA breakdown →