SYNDIG1L

Across TCGA patient cohorts, SYNDIG1L mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SYNDIG1L-associated genes across cancer lineages are EGFR_pY1068, MAPK_pT202_Y204, and Notch1. Each is linked with SYNDIG1L in more than 1 cancer types. Because this analysis shows association rather than direction, both SYNDIG1L-to-partner and partner-to-SYNDIG1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SYNDIG1L-low versus SYNDIG1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SYNDIG1L→partner) and Y-score (partner→SYNDIG1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.311	-3.000	.032	.037	3	1
UCEC	MAPK_pT202_Y204 →	-0.544	-3.000	.045	.037	3	1
UCEC	Notch1 →	+0.301	+2.820	<.001	.035	3	1
UCEC	RAD51 →	+0.215	+3.000	.007	.037	3	1
UCEC	TAZ →	-0.169	-3.000	.038	.037	3	1
UCEC	EGFR →	-0.298	-3.000	.001	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by SYNDIG1L expression — UCEC

Explore this box plot interactively →